Levitra is a drug that requires a medical prescription, its other name is Vardenafil HCl/Vardenafil Hydrochloride. Its main usage is treating impotence in men. This cure eases the expansion of the muscles in the artery walls, improving the blood supply to the penis.
Information and History
Levitra, back in the day, was a part of a revolution – a unique kind of drug was created for the ED treatment, they were called PDE5 inhibitors. Prior to that, ED was mostly considered a physical problem – thanks to Levitra, now people known that impotence is caused by a variety of bodily alignments, including heart issues, diabetes, hypertension, advanced age, etc. Before Vardenafil and various other PDE5 inhibitors were discovered, patients suffering from ED resorted to implants or shot up questionable substances into their penises.
Vardenafil was created way back in 2005 and it was co-marketed by Schering-Plough, GlaxoSmithKline, and Bayer HealthCare as Levitra. The manufacturer wanted to make Viagra’s formula even better, for example, remove most of the harmful interaction with food, so the users will not have to worry about every single thing they eat. Another part of what made Vardenafil so ground-breaking at the time is that it lessened the chance of premature ejaculation, a feature nowhere to be seen in other PDE5 inhibitors. On average, this drug is more popular and effective in comparison to the alternatives.
Levitra’s primary usage is curing ED. This drug hinders a certain type of enzyme (hence the name, PDE5 inhibitor). When a user experiences sexual stimulus after ingesting the pill, the circulation to the penis gets significantly increased, making maintaining/getting an erection easier. Methods of usage As per usual, we strongly suggest you check the leaflet containing all the needed information prior to using any tablets. In case you have any further questions, it’s better to have a conversation with your druggist or your MD.
It’s an oral administration pill. You must take Levitra approximately 60 minutes before you engage in intercourse, food or no food is not important. You can’t take more than one dosage per day. You must wait at least twenty-four hrs.
The dose itself depends heavily on your existing conditions, interaction with different meds and treatments you might be undergoing.
The dose that you should start with is 10 mg. Take it orally, approximately sixty mins before your scheduled intercourse. You must either increase or decrease it to 20 mg/5 mg, judging by your body’s reaction. The max dose is 20 mg per day.
People undergoing long-acting alpha 1 blocker treatment are only allowed 5 mg orally only one time per day. Men 65 years and older also should take only 5 mg per day. You also need to be wary of the fact that sexual stimulus is needed for this drug to work.
You should get medical assistance right away in case you encounter any symptoms of an adverse reaction to Levitra: angioedema, urticaria or breathing issues. Stop taking this tablet in case you encounter sudden blindness. During the intercourse, if you feel like you’re about to faint or if you feel nauseous – stop, call your MD instantaneously.
You also must refrain from using the drug if you encounter one of the below mentioned:
- Impaired vision.
- Tinnitus and/or sudden deafness.
- Chest pressure, sweating, i.e. early signs of a cardiac arrest.
- Swollen feet, ankles or hands.
- Painful erections that can persist up to four hours or longer.
Among Vardenafil side-effects, these are the most prevalent:
- Feeling dizzy.
- Abdominal pain.
- Cold sweat.
What you see above is not a full listing of all possible adverse effects. The most prevalent side-effect that people mention is a headache. If you feel something not mentioned in the list, you still must contact your doctor. This is serious, possible health complication may lead to serious consequences and, ultimately, death.
Warnings and Precautions
You should definitely talk to your MD before you start using this treatment. You have to make sure there won’t be any allergic reactions to Vardenafil.
There has to be an extensive PMH check. If you had heart issues during the last five months, if you had kidney issues, liver issues, hypotension or hypertension, dehydration, penis issues, prolonged/painful erections, eye issues, peptic ulcers.
This pill may also mess with the heartbeat, which usually leads to grave consequences. The risk is decreased/increased based on your PMH and the pills you’re using, because some may also affect your heartbeat.
The drug’s well-known side-effects include wooziness and vision changes, so you shouldn’t drive, operate heavy equipment or perform any activity that requires you to stay alert. You must also limit your liquor intake. We will say more on that in a different column, but still – alcohol and Vardenafil do not mix. One more product to avoid at all costs: grapefruits. Once again, more on that later.
If you notice someone experiencing symptoms such as fainting and/or troubled breathing, do not hesitate to call 911. The overdose tell-tale signs can also include: spinal pain, myalgia, impaired vision.
You cannot share this pill with others. There won’t be any issues if you “miss” a dose, because this treatment is only necessary if you’re about to engage in sexual activities.
Vardenafil must be stored at room temperature, you need to keep it away from lights and wetness. It needs to be kept away from kids and animals. Always check the expiration date.
Mechanism of action
Once a person becomes aroused, the brain sends signals via the nervous system. Some of the information sent gets transferred by the signals inside the tissue of the male sexual organ. The most important one is Cyclic guanosine monophosphate. This signal’s main goal is to calm the muscular layer to ease the blood supply, so the vessels are wide and there’s constant circulation to the penis. That’s how an erection happens.
Once a person reaches climax, one more chemical rushes through their body. PDE-5, one of the chemicals, can easily break down Cyclic GMP. The vessels go back to their normal state and penis becomes flaccid. Since Vardenafil is a PDE5 inhibitor, it blocks it out entirely, so it doesn’t disturb Cyclic guanosine monophosphate. The arteries don’t return back to their original state and the blood supply to the penis remains intense. That way, a user gets prolonged, strong erections.
Interactions with other pills may disrupt the original drug’s intended effect and can lead to serious adverse effects. This web-page doesn’t include all drug interaction, so what you should do is get a list of all the drugs you’re taking right now and give it to your doctor, so they can cross-reference it.
As a rule of thumb, never take Vardenafil with comparable drugs, including Viagra, Cialis, and Stendra. Do your own research, because the same meds have other names when they’re used to treat different conditions.
Here are some pills that cause issues:
- PDE5 inhibitors;
- Antibacterials, including azithromycin, erythromycin, clarithromycin, telithromycin (HMR 3647), and cethromycin (ABT-773);
- Antifungal agents, including azoles, fluconazole and itraconazole, and others;
- HBP medications/BPH medications, including doxazosin, terazosin, alfuzosin, tamsulosin, and silodosin;
- Medications for arrhythmia, including amiodarone, disopyramide, dofetilide, dronedarone, flecainide, propafenone, and sotalol;
- Antiretroviral drugs, including saquinavir, indinavir, ritonavir, nelfinavir, amprenavir, fosamprenavir, lopinavir, atazanavir, tipranavir, and darunavir.
- Just to reiterate, this selection is not 100% full. Other pills that may affect Vardenafil’s effectiveness include OTC medicines, prescription pills, vitamins, and herbs.
Vardenafil & grapefruit, Vardenafil & liquor
Two of the things that keep on getting mentioned over and over again when it comes to the side-effects and adverse reactions – grapefruits and liquor. Here is why you shouldn’t use them along with Vardenafil. To put it bluntly, grapefruits and grapefruit juices nullify this drug’s effects. Due to the certain substances that interfere with a certain enzyme, metabolism of the drug gets significantly lowered. It not only renders it ineffective, it also causes it to stay in the body longer than intended. A delay in metabolism can lead to a drug overdose. To avoid this dangerous interaction, if you have taken grapefruit you mustn’t use Vardenafil for at least 72 hours.
There’s no concrete evidence that alcohol actually presents any severe effects. Actually, it’s best to know that possible interactions may happen if these two substances are taken together. Even though research shows that liquor may be harmless for men taking ED drugs, health specialists suggest curbing your liquor intake while taking this ED pill. Because of the fact that Vardenafil is a PDE5 inhibitor, the risk of harmful side-effects must never be overlooked. To avoid potential interactions, you should simply drink less. Drink in small doses and see how you feel. If you notice anything even remotely out of the ordinary, stop drinking.
How to make Vardenafil work better?
Generally, you need to give these pills plenty of time to really start working. Be patient, you cannot expect an ED drug to give you a strong erection in a heartbeat. You can always have a conversation with your MD and find out whether you need to alter the prior dose. Never do this on your own, never ever. Always talk to your doctor before altering the dosage.
One of the most important aspects that people overlook – take it easy. Don’t put too much pressure on yourself. The psychological aspect is incredibly important, and it can also impair your performance. If you spend too much time worrying about what-ifs, the drug might not work as well as intended. Talk to your partner, make sure you both feel at ease.
Tyler C.It is probably just me, but I gave each one of the main three ED drugs a go. I’ve made my choice, the best one for me was Levitra. No side effects after taking it for a good long while, the results are pretty impressive. I gotta say that Viagra lasts longer for some reason, but my erections are way more intense with Levitra. I reckon it’s entirely individual, but I want to recommend this one to all the people struggling with erectile dysfunction. Worked for me, hopefully it will work for you as well.
Jack E.I don’t think my problem is what you call an ED. I still had powerful erections, but I lost them during the act. Out of the blue, completely random. I think I have trouble maintaining it, not getting it. Does that count as an ED? Anyway, technicalities aside, Levitra was very effective for me. Gotta tell ya, having a pretty decent sexual life at the age of 76 is what brings me joy. You’re only as old as you feel. Granted, I ain’t a hormonal teenager I once was, but I still feel like a real man. Thanks, Levitra!
John L.60 years old. My doctor made me switch to Viagra, that one didn’t work out so well for me, stayed on Levitra. What can I say – the results are incredibly. There’s only one big IF – the results are incredible IF I work out. With no physical activity my body seems to think I’m ready to just lay down the arms and give up the fight. Speaking of Viagra, it gave no results at all. I even got mildly depressed and depression does affect your sexual prowess in the long run. Can’t have that! Levitra is good for me.
William K.So, I tried it. I’m only 45 years old, but I have a lot of stressful stuff going on in my life. I’m also overweight. I know, excuses-excuses, but that’s neither here nor there. Anyway, I tried it during the weekend, got a great experience with my wife out of it. She was pleasantly surprised. I didn’t mention the fact I took Levitra, it kind of makes me feel like a total loser. Yeah, right – she got burned out during the forth round. That should really tell you something. All happened in the span of 3-4 hours, took 20 mg dosage.